Connect with us


Pradaxa May Increase Flu Risks And Other Viral Infections

In a Pradaxa study conducted by the University of North Carolina, researchers were surprised to find that the next generation anticoagulant drug may contribute to elevated risk and increased severity of viral infections, including myocarditis, an inflammation of the heart that has resulted in death in children and young adults, and influenza.
Pradaxa was approved by the FDA to treat non-valvular atrial fibrillation, which is becoming increasingly common and is associated with an elevated risk of the patient developing life threatening blood clots. The drug minimizes clots by thinning the blood. Patients who use the drug may become more susceptible to viral infections because the drug blocks the activity of thrombin. Thrombin is an enzyme that plays an important role in the way in which blood clots. Blocking throbin’s activity reduces an aspect of the immune system’s response to viral infection.
How Clotting Works to Fight Infection
The several teams that worked on the study, including Charité – Universitätsmedizin in Berlin, Germany and the Mackman Group, did not anticipate that they would discover the increased viral infection risk that appears to be associated with Pradaxa. The finding was made as the group how the body’s cells respond to viruses. Although other studies reported findings which suggested that fibrin, a clotting protein that is formed by thrombin, is responsible for activating immune cells which attack bacteria, viruses, and other pathogens and digests them.
However, the researchers found that this belief is not accurate, concluding that the antiviral mechanism in the clotting system is linked directly to thrombin. Mackman explained that thrombin works by triggering the immune response by activating PAR-1,a type of receptor cell. The team studied the immune response by deactivating PAR-1 in mice. When the mice were infected with a myocarditis-causing virus, the team observed increased impairment of the heart function in the mice along with more viral buildup. The mice’s immune system also had a slower response after infection.
Applying the Study to Pradaxa
After discovering the impaired heart function, increased viral buildup, and slowed immune response in mice in which PAR-1 had been deactivated, researchers gave Pradaxa to normal mice. The mice that had been given Pradaxa exhibited the same symptoms as those in which the researchers had deactivated PAR-1. Macklan concluded that while Pradaxa may have significant lifesaving results when used to treat as an anticoagulant, the drug may also negatively impact other areas of health.
The study’s findings have led to the recognition of yet another possible risk patients must consider when taking Pradaxa. Approximately 4,000 complaints were filed with the FDA in 2011 citing serious adverse events, and 550 reports which cited deaths that were linked to the use of Pradaxa were also received. As a result, over 250 Pradaxa lawsuits were consolidated and are now pending in the U.S. District Court for the Southern District of Illinois. The team plans for its next study to examine warfarin. Warfarin is has been prescribed more than any other blood thinner for decades.
Authored By: Renee Simmons. Renee is a journalist/blogger who contributes new legal information across different websites and organizations.

Continue Reading

Recent Posts

Business4 weeks ago

Your Basic Guide To Creating A Unique Investment Blog

Starting your own blog is great and once you get the ball rolling, it can be a good passive income...

Business4 weeks ago

3 Low-Risk Ways To Get Your New Business Started

Once you’ve got an initial business idea and believe that it will be a success, there are some basic things...

Lifestyle1 month ago

Conquering the Co-free Zone: Tips for Thriving as a Remote Worker

Adjusting to an office environment can come with its downfalls in the sense that it might be a shock to...

General2 months ago

3 Ways To Take Control Of Your Finances Starting Now

If your finances have taken over and are bringing stress to your life, we understand just how overwhelming it can...

Travel4 months ago

Best Places To Visit In The North Of England

If you live in England, you will know there are many different places to visit for the weekend. There are...

General4 months ago

Green Home Improvement Ideas

In a world where environmental concerns are growing, the concept of “green” has gone beyond a trendy catchphrase and is...

Lifestyle4 months ago

How to Host an Unforgettable House-Warming!

The time has finally come. You have moved into your dream pad, and are officially adulting in your very own...

Autos4 months ago

A Guide to Parking Lot Striping

The journey to a well-striped parking lot begins with the right paint. In this brief guide, we’ll unravel the mystery...

Business7 months ago

Business Tips For Protecting Your Finances During A Recession

In 2023, taking the necessary steps to protect your finances for your business is now more important than ever. The...

Lifestyle8 months ago

Tips For Cleaning Your Trainers

If you’re into your trainers and streetwear, you’re likely to be very conscious of keeping them looking their best! So,...

Marketing8 months ago

Branding Trends For Start-Ups in 2023

Branding is incredibly important as it impacts how your business reaches and connects with its target market. If you’re branding...

Business8 months ago

Avoiding the Wrong Kind of Growth

Growth is vital for any business – some models, like tech start-ups, are built around periods of dramatic, explosive growth...

Business8 months ago

How To Become A Property Developer

There are several reasons why an individual will want to become a property developer. One of the main reasons for...

Tech11 months ago

What Is The Difference Between Cyber Attacks and Cyber Threats?

If you own a business that uses the cloud to manage workloads, you have probably heard of the terms cyberattack...

Marketing11 months ago

3 Types of Marketing Every Small Construction Business Should Do

Construction is a very saturated sector, whether you’re a large or small construction company, so marketing should be at the...